Active Ingredients:

• progesterone

Therapeutic actions: Prometrium- Endometrin contains the active ingredient progesterone that is the yellow body's hormone. Progesterone works by causing the transition of endometrium from the proliferation phase into secretory one. After impregnation progesteron creates favorable conditions for the fertilized egg development. Progesterone decreases the affectability and contractility of the womb and uterine tubes muscles as well as stimulates the development of the lacteal gland.

Indications: Prometrium- Endometrin is used to treat the following conditions:

• Conditions caused by insufficiency of progesterone
• Premenstrual stress syndrome

Dysmenorrhea

• Mastopathy
• Premenapause
• Deficiency of progesterone in premenapause
• Substitute therapy of menapause(in combination with estrogen medication)

For the intra-vaginal application:

• Substitute hormonotherapy with the nonfunctioning ovaries in the case of the complete absence of progesterone (with the blood donation of egg cells)
• The maintenance of lutein phase during the preparation for the extracorporeal fertilization
• The maintenance of lutein phase in the spontaneous or induced menstrual cycle
• Sterility as a result of the lutein phase insufficiency;
• The prophylaxis of miscarriage as a result of progestin insufficiency;
• The threat of pregnancy disruption
• Endocrine sterility

Contraindications and cautions: You should not use this medication:

• If you have hypersensitivity to progesterone
• In 2 or 3 pregnancy trimester
• Kidney or liver failure

Warning!

• Do not use Prometrium- Endometrin as contraceptive medication.
• Do not or operate any machinery while taking this medication.

Adverse effects: There are possible side-effects associated with this medicine that can affect individuals in different ways. If a side effect is stated here, that does not necessarily mean the fact that all people using Prometrium- Endometrin will experience it or any other.

• Drowsiness
• Dizziness
• Intermenstrual bleeding
• Reducing menstrual cycle.

The side effects listed above may not include all of the side effects reported by the drug's manufacturer. For more information about any other possible risks associated with Prometrium- Endometrin, please read the information provided with Prometrium- Endometrin or consult your doctor or pharmacist.

Interactions: It is important to tell your doctor or pharmacist what medicines you are already taking, including those bought without a prescription and herbal medicines, before you start treatment with Prometrium- Endometrin. Similarly, check with your doctor or pharmacist before taking any new medication while taking this one, to ensure that the combination is safe.

Especially pay attention to hormonal therapy.

Additional Information: DO NOT SHARE Prometrium- Endometrin with others. DO NOT USE THIS MEDICINE for other health conditions. KEEP THIS PRODUCT, as well as syringes and needles, if needed during treatment, out of the reach of children. Do not reuse needles, syringes, or other materials.