Gonal-F 450 IU (follitropin alfa for injection) is a highly consistent recombinant human follicle-stimulating hormone (r-hFSH), Filled by Mass (FbM). This medication is prescribed to supplement or replace naturally occurring FSH, an essential hormone that is used to treat infertility in both women and men. Gonal-F 450 IU has been approved in over 90 countries worldwide both in Europe and the US with indications of stimulation of the growth of ovarian follicles and ovulation in women. Gonal F is the most widely prescribed gonadotropin in the world.

The role of human FSH in the body:

Human follicle stimulating hormone (FSH) helps in the development of follicles in the ovaries. This is an essential step in the development of mature oocytes (eggs) that are ready for fertilization. FSH is also necessary for the production of healthy spermatozoa in men. Low or lack of secretion of human FSH is a major cause of infertility.

Gonal-F 450 IU (FbM) Prefilled Pen

The Gonal-F 450 IU (FbM) Prefilled Pen has a simple and effective design that is ideal for self-administration by the patient. It does not need reconstitution or cartridge assembly into the injection device, thereby reducing the number of steps before injection and helping ensure an accurate dose. It is available in three multi-dose presentations (300, 450 and 900 IU) allowing individualized dosing of r-hFSH to individual patient needs in both OI (Ovulation Induction) and ART (Assisted Reproductive Techniques).

Precautions While Using Gonal-F 450 IU:

Gonal-F 450 IU is a potent gonadotropic substance capable of causing mild to severe adverse reactions, including Ovarian Hyperstimulation Syndrome (OHSS) in women with or without pulmonary or vascular complications, and multiple births. Gonal-F 450 IU is contraindicated in women who exhibit prior hypersensitivity to FSH preparations, primary gonadal failure, uncontrolled thyroid or adrenal dysfunction and pregnancy. Nursing women should not use Gonal-F 450 IU®. Common side effects include headache, abdominal pain, enlarged abdomen, and injection site disorders. For complete product details, see full prescribing information.